Ukwazisa i-PQQ: I-Ultimate Energy Booster yeNgqondo nomzimba

Ukwazisa i-PQQ: I-Ultimate Energy Booster yeNgqondo nomzimba

I-Pyrroloquinoline quinone, ekubhekiselwa kuyo njenge-PQQ, liqela elitsha leprosthetic elinemisebenzi efana neyomzimba kwiivithamini. Ifumaneka ngokubanzi kwiiprokaryotes, izityalo kunye nezilwanyana ezincancisayo, ezifana neembotyi zesoya okanye i-natto, i-pepper eluhlaza, iziqhamo ze-kiwi, i-Parsley, iti, i-papaya, isipinashi, i-celery, ubisi lwebele, njl.

Kwiminyaka yakutshanje, i-PQQ iye yaba yenye yezondlo "zeenkwenkwezi" eziye zatsala ingqalelo ebanzi. Ngo-2022 kunye no-2023, ilizwe lam lavuma i-PQQ eveliswe ngokudibanisa kunye nokuvundiswa njengezinto ezintsha zokutya.

Imisebenzi yebhayoloji ye-PQQ igxile kakhulu kwimiba emibini. Okokuqala, inokuxhasa ukukhula kunye nokuphuhliswa kwe-mitochondria kunye nokukhuthaza ukukhula ngokukhawuleza kweeseli zomntu; okwesibini, ineempawu ezilungileyo ze-antioxidant, ezinokunceda ukususa i-radicals yamahhala kunye nokunciphisa umonakalo weseli. Le misebenzi mibini iyenza idlale indima enamandla kwimpilo yengqondo, impilo yentliziyo, impilo yemetabolism kunye neminye imiba. Kuba umzimba womntu awukwazi ukwenza i-PQQ ngokwawo, kufuneka yongezwe ngezongezo zokutya.

Indima ye-01.PQQ ekuphuculeni ukuqonda ixatyiswe ngokukodwa

NgoFebruwari 2023, abaphandi baseJapan bapapasha iphepha lophando elinesihloko esithi "Pyrroloquinoline quinone disodium ityuwa iphucula ukusebenza kwengqondo kubo bobabini abancinci nabadala" kwiphephancwadi elithi "Ukutya & Umsebenzi", ukwazisa ulwazi lwe-PQQ kubantu abancinci kunye nabantu abadala eJapan. Iziphumo zophando eziphuculweyo.

Olu phononongo lwaluyi-double blind-blind placebo randomized controlled trial ebandakanya amadoda angama-62 asempilweni aseJapan aneminyaka eyi-20-65 iminyaka, kunye namanqaku e-Mini-Mental State Scale ≥ 24, abagcina indlela yabo yokuphila yangaphambili ngexesha lokufunda. Isihlwele sabasetyhini. Izifundo zophando zahlulwe ngokungaqhelekanga kwiqela lokungenelela kunye neqela lokulawula i-placebo, kwaye zalawulwa ngomlomo nge-PQQ (20 mg / d) okanye i-placebo capsules imihla ngemihla kwiiveki ze-12. Inkqubo yovavanyo lwe-intanethi ephuhliswe yinkampani yasetyenziselwa ukuchongwa kwiiveki 0/8/12. Uvavanyo lokuqonda luvavanya le misebenzi yobuchopho ili-15 ilandelayo.

Iziphumo zibonise ukuba xa kuthelekiswa neqela lolawulo lwe-placebo, emva kweeveki ze-12 zokuthatha i-PQQ, imemori edibeneyo kunye namanqaku eenkumbulo zomlomo kuwo onke amaqela kunye neqela elidala liye landa; emva kweeveki ezisi-8 zokuthatha i-PQQ, ukuguquguquka kwengqondo yeqela elincinci, isantya sokusebenza kunye nesantya sokuPhunyezwa sandisiwe.

02 I-PQQ ayinakuphucula kuphela ukusebenza kwengqondo yabantu abadala, kodwa ikwaphucula impendulo yengqondo yabantu abatsha!

NgoMatshi ka-2023, ijenali eyaziwayo kwihlabathi lokutya kunye nomsebenzi wapapasha iphepha lophando elinesihloko esithi "Pyrroloquinoline quinone disodium ityuwa iphucula ukusebenza kwengqondo kubantu abadala nabancinci". Olu phononongo luphande ifuthe le-PQQ ekusebenzeni kwengqondo yabantu abadala abaneminyaka engama-20-65, ukwandisa inani lophononongo lwe-PQQ ukusuka kubantu abadala ukuya kwabaselula. Uphononongo lubonakalise ukuba i-PQQ inokuphucula umsebenzi wokuqonda wabantu bayo yonke iminyaka.

Uphando lufumene ukuba i-PQQ, njengokutya okusebenzayo, inokuphucula ukusebenza kwengqondo kuyo nayiphi na iminyaka, kwaye kulindeleke ukuba yandise ukusetyenziswa kwe-PQQ njengokutya okusebenzayo ukusuka kubantu abadala ukuya kubantu bayo yonke iminyaka.

03 I-PQQ isebenza njenge-activator "yeefektri zamandla eseli" ukubuyisela impilo yabo

NgoMeyi ka-2023, i-Cell Death Dis yapapasha iphepha lophando elinesihloko esithi Ukutyeba kakhulu kuphazamisa i-cardiolipin-dependent mitophagy kunye nonyango lwe-intercellular mitochondrial transfer ability of mesenchymal stem cells. Olu phononongo lufumanise i-PQQ ngokuphonononga ukuba ngaba i-intercellular mitochondrial donor umthamo wezifundo ezityebe kakhulu (abantu abanengxaki ye-metabolic) kunye nefuthe lonyango lweeseli ze-mesenchymal stem (MSCs) zonakele, kunye nokuba unyango olujoliswe kwi-mitochondrial lunokuzibuyisela umva na. Ukumodareyitha kubuyisela impilo ye-mitochondrial ukunciphisa ukukhubazeka kwe-mitophagy.
Olu phononongo lubonelela ngengqiqo yokuqala ebanzi yemolekyuli yokuphazamiseka kwe-mitophagy kwiiseli ze-mesenchymal stem eziphuma kukutyeba kwaye lubonisa ukuba impilo ye-mitochondrial inokubuyiselwa ngomgaqo we-PQQ ukunciphisa i-mitophagy.

I-04 PQQ inokuphucula ukusebenza kwemetabolism yomntu

NgoMeyi ka-2023, inqaku lophononongo elinesihloko esithi "Pyrroloquinoline-quinone ukunciphisa ukuqokelelwa kwamafutha kunye nokuphucula ukuqhubela phambili kokutyeba" lapapashwa kwijenali Front Mol Biosci, eyayishwankathela izifundo zezilwanyana ezi-5 kunye nezifundo ezi-2 zeeseli.
Iziphumo zibonisa ukuba i-PQQ inokunciphisa amanqatha omzimba, ngakumbi i-visceral kunye nokuqokelelwa kwamafutha esibindi, ngaloo ndlela ithintela ukutyeba kokutya. Ukusuka kuhlalutyo lomgaqo, i-PQQ ikakhulu inqanda i-lipogenesis kwaye inciphisa ukuqokelelwa kwamafutha ngokuphucula ukusebenza kwe-mitochondrial kunye nokukhuthaza i-lipid metabolism.

05 I-PQQ inokuthintela i-osteoporosis ebangelwa kukwaluphala kwendalo

NgoSeptemba ka-2023, i-Aging Cell yapapasha iphepha lophando elinesihloko esithi "Pyrroloquinoline quinone inciphisa i-osteoporosis enxulumene nokwaluphala ngenoveli ye-MCM3-Keap1-Nrf2-mediated-mediated stress response and Fbn1 upregulation" kwi-intanethi. Uphononongo, ngovavanyo kwiimpuku, lufumanise ukuba izongezo zokutya ze-PQQ zinokuthintela i-osteoporosis ebangelwa kukwaluphala kwendalo. Indlela esisiseko ye-PQQ yamandla e-antioxidant enamandla ibonelela ngesiseko sovavanyo sokusetyenziswa kwe-PQQ njengesongezo sokutya sothintelo lwe-osteoporosis enxulumene nobudala.
Olu phononongo lutyhila indima esebenzayo kunye nendlela entsha ye-PQQ ekuthinteleni nasekunyangeni i-senile osteoporosis, kwaye ingqina ukuba i-PQQ inokusetyenziswa njengezongezo ezikhuselekileyo nezisebenzayo zokutya ukuthintela kunye nokunyanga i-senile osteoporosis. Ngelo xesha, kwavezwa ukuba i-PQQ isebenze i-MCM3-Keap1-Nrf2 isignali kwi-osteoblasts, i-transcriptally ilawula ukubonakaliswa kweejene ze-antioxidant kunye ne-Fbn1, inqanda uxinzelelo lwe-oxidative kunye ne-osteoclast bone resorption, kwaye ikhuthaza ukubunjwa kwamathambo e-osteoblast, ngaloo ndlela ikhusela ukuguga. Indima ekusekweni kwe-osteoporosis ngokwesondo.

06 Ukuncedisa i-PQQ kunokukhusela iiseli ze-retinal ganglion kunye nokuphucula impilo yamehlo!

NgoSeptemba 2023, iphephancwadi i-Acta Neuropathol Commun yapapasha uphando oluvela kwiingcali ze-ophthalmology ezifanelekileyo kunye nabaphengululi be-Eye Hospital ye-Karolinska Institutet e-Stockholm, eSweden, isikolo esidumileyo sezonyango saseYurophu, kunye ne-Royal Victoria Eye kunye ne-Ear Hospital e-Australia, kunye neSebe le-Biology yeYunivesithi yasePisa e-Italy. Inesihloko esithi "i-Pyrroloquinoline quinone iqhuba i-ATP synthesis in vitro kunye ne-vivo kwaye ibonelela nge-retinal ganglion cell neuroprotection." Uphando luye lwangqina ukuba i-PQQ inefuthe elikhuselayo kwiiseli ze-retinal ganglion (RGC) kwaye inamandla amakhulu njenge-neuroprotective agent entsha ekuxhathiseni i-retinal ganglion cell apoptosis.
Iziphumo zixhasa indima enokubakho ye-PQQ njengenoveli ye-neuroprotective agent enokuthi iphucule ukomelela kweeseli ze-retinal ganglion ngelixa inciphisa umngcipheko weziphumo ebezingalindelekanga. Kwangaxeshanye, abaphandi bakholelwa ukuba ukongeza i-PQQ lukhetho olusebenzayo lokugcina impilo yamehlo.

07 Ukuncedisa i-PQQ kunokulawula i-intestinal flora, ukuphucula ukusebenza kwe-thyroid, kunye nokunciphisa umonakalo we-thyroid.

NgoDisemba ka-2023, iqela lophando elivela kwiSibhedlele se-Shanghai seshumi sabantu kwiYunivesithi yaseTongji yeSikolo sezoNyango sapapasha inqaku elinesihloko esithi "Indima enokwenzeka ye-Pyrroloquinoline Quinone yokulawula i-Thyroid Function kunye ne-Gut Microbiota Ukubunjwa kweSifo seMangcwaba kwiiMice" kwiphephancwadi iPol J Microbiol Kweli nqaku, abaphandi babonisa ukuba imodeli ye-Pyrroloquinoline iyakwazi ukuncedisa i-mouse ye-Q florte. ukunciphisa umonakalo wamathumbu, kunye nokuphucula umsebenzi we-thyroid.
Uphononongo lufumene iziphumo zokuxhaswa kwe-PQQ kwiimpuku ze-GD kunye neentyatyambo zazo zamathumbu:

I-01 Emva kokuxhaswa kwe-PQQ, i-serum TSHR kunye ne-T4 yeegundane ze-GD zancitshiswa, kwaye ubukhulu be-thyroid gland buncitshiswe kakhulu.

02 I-PQQ inciphisa ukudumba kunye noxinzelelo lwe-oxidative, kwaye inciphisa umonakalo omncinci we-epithelial wamathumbu.

03 I-PQQ inempembelelo ebalulekileyo ekubuyiseleni iyantlukwano kunye nokwakhiwa kwe-microbiota.

I-04 xa kuthelekiswa neqela le-GD, unyango lwe-PQQ lunokunciphisa ubuninzi beLactobacilli kwiigundane (oku kunyango olujoliswe kuyo kwinkqubo ye-GD).

Isishwankathelo, ukuxhaswa kwe-PQQ kunokulawula ukusebenza kwe-thyroid, ukunciphisa umonakalo we-thyroid, kunye nokunciphisa ukuvuvukala kunye noxinzelelo lwe-oxidative, ngaloo ndlela kunciphisa umonakalo omncinci we-epithelial wamathumbu. Kwaye i-PQQ inokubuyisela ukwahluka kweentyatyambo zamathumbu.

Ukongeza kwezi zifundo zingentla zingqina indima ephambili kunye namandla angenamkhawulo we-PQQ njengesongezelelo sokutya sokuphucula impilo yabantu, izifundo zangaphambili ziqhubekile nokuqinisekisa imisebenzi enamandla ye-PQQ.

08 I-PQQ inokuphucula uxinzelelo lwegazi lwemiphunga

Ngo-Okthobha ka-2022, iphepha lophando elinesihloko esithi "Pyrroloquinoline quinone (PQQ) iphucula uxinzelelo lwegazi lwe-pulmonary ngokulawula imisebenzi ye-mitochondrial kunye ne-metabolic" yapapashwa kwiphephancwadi i-Pulmonary Pharmacology & Therapeutics, ejolise ekuphononongeni indima ye-PQQ ekuphuculeni uxinzelelo lwegazi lwe-pulmonary.
Iziphumo zibonisa ukuba i-PQQ inokunciphisa ukungahambi kakuhle kwe-mitochondrial kunye nokungahambi kakuhle kwe-metabolic kwi-pulmonary artery smooth muscle cells kunye nokulibazisa ukuqhubela phambili koxinzelelo lwe-pulmonary hypertension kwiimpuku; ke ngoko, i-PQQ ingasetyenziswa njengearhente yonyango enokubakho ukuphucula uxinzelelo lwegazi lwepulmonary.

09 I-PQQ inokulibazisa ukuguga kweeseli kwaye yandise ubomi!

NgoJanuwari ka-2020, iphepha lophando elinesihloko esithi Pyrroloquinoline quinone ilibazisa ukudumba okubangelwa yi-TNF-α ngokusebenzisa i-p16/p21 kunye ne-Jagged1 iindlela zokubonisa ezipapashwe kwi-Clin Exp Pharmacol Physiol yaqinisekisa ngokuthe ngqo isiphumo sokulwa nokuguga kwe-PQQ kwiiseli zabantu. , iziphumo zibonisa ukuba i-PQQ ilibazisa ukuguga kweeseli zomntu kwaye inokwandisa ubomi.

Abaphandi bafumanise ukuba i-PQQ inokulibazisa ukuguga kweeseli zomntu, kwaye yasiqinisekisa ngakumbi esi sigqibo ngeziphumo zokubonakaliswa kwee-biomarkers ezininzi ezifana ne-p21, p16, kunye ne-Jagged1. Kucetyiswa ukuba i-PQQ inokuphucula impilo yabantu ngokubanzi kwaye yandise ixesha lokuphila.

I-10 PQQ inokuthintela ukuguga kwe-ovarian kunye nokugcina ukuchuma

Ngo-Matshi ka-2022, iphepha lophando elinesihloko esithi "I-PQQ Izongezo zokutya zithintela i-Alkylating Agent-Induced Ovarian Dysfunction in Mice" yapapashwa kwijenali ye-Front Endocrinol, ejonge ukufunda ukuba izongezo zokutya ze-PQQ zikhusela ukungasebenzi kakuhle kwe-ovarian ye-alkylating arhente. isiphumo.
Iziphumo zibonise ukuba ukuxhaswa kwe-PQQ kwandisa ubunzima kunye nobukhulu bee-ovari, ngokuyinxenye kubuyisele umjikelo owonakeleyo we-estrous, kwaye kuthintele ukulahleka kweefollicles kwiimpuku eziphathwe nge-alkylating agents. Ngaphaya koko, ukuxhaswa kwe-PQQ konyusa kakhulu izinga lokukhulelwa kunye nobungakanani benkunkuma ngokuziswa kweempuku ezinyangwa yi-alkylating. Ezi ziphumo ziqaqambisa ukungenelela okunokwenzeka kokuxhaswa kwe-PQQ kwi-alkylating agent-induced ovarian dysfunction.

Ukuqukumbela
Ngapha koko, njengesongezelelo esitsha sokutya, i-PQQ iye yamkelwa ngenxa yeziphumo zayo ezilungileyo kwisondlo nakwimpilo. Ngenxa yemisebenzi yayo enamandla, ukhuseleko oluphezulu kunye nokuzinza okulungileyo, inamathuba ophuhliso olubanzi kwintsimi yokutya okusebenzayo.
Kwiminyaka yakutshanje, ngokukhula kolwazi, i-PQQ iphumelele esona satifikethi sisebenza ngokugqibeleleyo kwaye isetyenziswa ngokubanzi njengesongezelelo sokutya okanye ukutya e-United States, eYurophu nakwamanye amazwe nakwimimandla. Njengoko ulwazi lwabathengi basekhaya luqhubeka nokukhula, kukholelwa ukuba i-PQQ, njengesithako esitsha sokutya, iya kudala ihlabathi elitsha kwimarike yasekhaya.

IiReferensi:

1.TAMAKOSHI M, SUZUKI T, NISHIHARA E, et al. IPyrroloquinoline quinone disodium ityuwa iphucula ukusebenza kwengqondo kubo bobabini abancinci nabadala [J]. Ukutya kunye nomsebenzi, 2023, 14 (5): 2496-501.doi: 10.1039/d2fo01515c.2. Masanori Tamakoshi,Tomomi Suzuki,Eiichiro Nishihara,et al. IPyrroloquinoline quinone disodium ityuwa iphucula ukusebenza kwengqondo kubo bobabini abancinci nabadala. Umsebenzi woKutya oLawulwayo ngokungakhethiyo. 2023 Mar 6;14(5):2496-2501. PMID: 36807425.3. UShakti Sagar, uMd Imam Faizan, uNisha Chaudhary, et al. Ukutyeba ngokugqithiseleyo kuphazamisa i-cardiolipin exhomekeke kwi-mitophagy kunye ne-trapeutic intercellular mitochondrial transfer transfer of mesenchymal stem cells. Ukufa Kweseli Dis. 2023 Meyi 13;14(5):324. doi: 10.1038/s41419-023-05810-3. PMID: 37173333.4. Nur Syafiqah Mohamad Ishak , Kazuto Ikemoto. I-Pyrroloquinoline-quinone yokunciphisa ukuqokelelwa kwamafutha kunye nokuphucula ukuqhubela phambili kokutyeba. FrontMolBiosci.2023Meyi5:10:1200025. doi: 10.3389/fmolb.2023.1200025. PMID: 37214340.5.Jie Li, Jing Zhang, Qi Xue, et al. I-Pyrroloquinoline quinone inciphisa i-osteoporosis enxulumene nokwaluphala ngokusebenzisa inoveli ye-MCM3-Keap1-Nrf2 i-axis-mediated-mediated response response kunye ne-Fbn1 yolawulo. Ukuguga kweSeli. 2023 Sep;22(9):e13912. doi: 10.1111/acel.13912. Epub 2023 Jun 26. PMID: 37365714.6. UAlessio Canovai, uJames R Tribble, uMelissa Jöe. njl. al. I-Pyrroloquinoline quinone iqhuba i-ATP synthesis in vitro kunye ne-vivo kwaye ibonelela nge-retinal ganglion cell neuroprotection. Acta Neuropathol Commun. 2023 Sep 8;11(1):146. doi: 10.1186/s40478-023-01642-6. PMID: 37684640.7. Xiaoyan Liu , Wen Jiang , Ganghua Lu , et al. Indima enokwenzeka ye-Pyrroloquinoline Quinone yokulawula umsebenzi we-Thyroid kunye ne-Gut Microbiota Ukuqulunqwa kwezifo ze-Graves kwiiMice. Pol J Microbiol. 2023 Dec 16; 72 (4): 443-460. doi: 10.33073/pjm-2023-042. eCollection 2023 Dec 1. PMID: 38095308.8. UShafiq, uMohammad et al. "I-Pyrroloquinoline quinone (PQQ) iphucula uxinzelelo lwegazi lwe-pulmonary ngokulawula imisebenzi ye-mitochondrial kunye ne-metabolic." I-Pulmonary Pharmacology & therapeutics vol. 76 (2022): 102156. doi:10.1016/j.pupt.2022.1021569. Ying Gao, Teru Kamogashira, Chisato Fujimoto. okqhubekayo. I-Pyrroloquinoline quinone ilibazisa ukuvuvukala okubangelwa yi-TNF-α ngokusebenzisa i-p16/p21 kunye ne-Jagged1 iindlela zokubonisa. Clin Exp Pharmacol Physiol. 2020 Jan;47(1):102-110. doi: 10.1111/1440-1681.13176. PMID: 31520547.10.Dai, Xiuliang et al. "I-PQQ yokongezwa kokutya iNqanda i-Alkylating Agent-Induced Ovarian Dysfunction kwiiMice." Imida kwi-endocrinology vol. 13 781404. 7 Mar. 2022, doi:10.3389/fendo.2022.781404