Ukwazisa i-pqq

Ukwazisa i-pqq

I-Pyrequinequineline Quinene, ekubhekiswa kuyo njenge-PQQ, liqela elitsha le-prosthelity enomsebenzi ofanayo womzimba kwiivithamini. Ifunyenwe ngokubanzi kwi-prokarytes, izityalo nezilwanyana ezincancisayo, ezinje nge-soybebbaans okanye i-natping, ipepile eluhlaza, i-pieles, papaya, i-celery, njl.

Kwiminyaka yakutshanje, i-PQQ ibe yenye yeesondlo "zenkwenkwezi" ezazitsala umdla obanzi. Ngo-2022 nowama-2023, ilizwe lam lavuma i-PQQ iveliswe yiSynthesi kunye nokuBuya njengezixhobo ezintsha zokutya.

Imisebenzi yendalo ye-PQQ igxile ikakhulu kwimiba emibini. Okokuqala, inokuxhasa ukukhula kunye nophuhliso lwe-mitochondria kwaye ivuselele ukukhula ngokukhawuleza kweeseli zabantu; Okwesibini, inepropathi elungileyo ye-antioxidant, enokunceda ukususa i-radicals yasimahla kwaye inciphise umonakalo weseli. Le misebenzi mibini yenza idlale indima enamandla kwimpilo yengqondo, impilo yentliziyo, impilo ye-metabolic kunye neminye imiba. Kuba umzimba womntu awunakuyifumana i-PQQ ngokwayo, kufuneka ixhaswe ngezongezo zokutya.

Indima ye-01.pqq ekuphuculeni ukuqonda ixabisa kakhulu

NgoFebruwari 2023, abaphandi baseJapan bapapasha i-TAP yoPhando "i-Pyreraquinoline Quindone ityiwa iphucula ukusebenza kwengqondo kubantu abancinci nabadala", bazise ulwazi lwe-PQQ kubantu abancinci. Iziphumo eziphuculweyo zophando.

Esi sifundo yayiyingxoxo engafunekiyo ye-coltical-engafunekiyo ebandakanya amadoda aseJapan aneminyaka engama-20 ukuya kwengama-65, enamanqaku amancinci e-Mini-Memonial State ≥ 24, ogcina ubomi babo bokuqala ngexesha lokufunda. Isihlwele sabafazi. Izifundo zophando zahlulwe ngokungacwangciswanga zaba liqela lokungenelela kunye neqela lolawulo lwe-placebo, kwaye zalawulwa nge-PQQ Inkqubo yovavanyo lwe-intanethi ephuhliswe yinkampani isetyenziselwe ukuchongwa kwiiveki 0/8/12. Uvavanyo lwengqondo luvavanya imisebenzi yengqondo elandelayo.

Iziphumo zibonise ukuba zithelekiswa neqela lolawulo lwe-placebo, emva kweeveki ezili-12 ze-PQQ, iinkumbulo ezihlanganisiweyo kunye namanqaku emowudi yamaqela awo onke amaqela akhulileyo ayanda; Emva kweeveki ezisi-8 ze-PQQ, ukutshintsha kweqela elincinci, ukulungisa isantya kunye nesantya sokwenza isantya senziwe.

I-02 PQQ ayikwazi ukuphucula ukusebenza kwengqondo yabantu abadala, kodwa iphucula impendulo yobuchopho abantu abancinci!

Ngo-Matshi 2023, ukutya okufundiswayo kwangaphandle kunye nomsebenzi owaziwayo iPhepha loPhando eliPhakathi "i-Pyreraquinoline Quindone i-quonesoodium iphucula ukusebenza kwengqondo kubantu abancinci nabadala". Olu phononongo luphandile ifuthe le-PQQ kumsebenzi wengqondo kubantu abadala abangama-20-65, ukwandisa abantu abafundayo be-PQQ kubantu abancinci. Isifundo sangqina ukuba i-PQQ inokuphucula ukusebenza kwengqondo yabantu bayo yonke iminyaka.

Uphando lufumanise ukuba i-PQQ, njengokutya okusebenzayo, kunokuphucula ukusebenza kwengqondo nangaliphi na iminyaka, kwaye kulindeleke ukuba kwandiswe ukusetyenziswa kwe-PQQ kubadala abantu bayo yonke iminyaka.

I-03 PQQ isebenza njengento eyiyo "ye-Ilfowuni yamandla" ukubuyisela impilo yazo

Ngomhla wamashumi amabini anesifo seeseli zokupapasha iPhepha loPhando elinikezwe i-OltiolIill Proniofin-Litophar I-Itrachendlight ye-Interculate MitoCholondal. Olu phando olufunyenweyo lwe-PQQ ngokuvavanya ukuba umthamo we-mitsellial ane-mitserllial anezifundo ze-thosebolic (abantu abane-metabolic) kunye nefuthe lonyango lweeseli ze-meseshym cer (i-MSCS) zinokubuyisa. Imodyuli ibuyisela impilo ye-mitochondlials ukunciphisa iMitophagy engalunganga.
Olu phononongo lubonelela ngokuqonda okuthe kratya okokuqala kwe-thotopha ekhulelweyo kwiiseli ze-cesseshysm ezihluthwe i-cemesm stem kwaye ibonisa ukuba impilo ye-mitochond inokuthi ibuyiselwe kummiselo we-PQQ.

I-04 PQQ inokuphucula umsebenzi we-tetabolic umntu

Ngomhla wamashumi amabini anesithandathu Meyi 2023, inqaku lokuphononongwa elithi "i-Pyrequinedineline-Quinequinedine-Quidone ukunciphisa ukuqhutywa kwamafutha kunye nokuqhubela phambili kwijenali yangaphambili yeJenuo Scosci, eshwankathelwe kwizifundo ezi-5 zeseli.
Iziphumo zibonisa ukuba i-PQQ ingawanciphisa amanqatha omzimba, ngakumbi i-visceral kunye ne-visceral kunye nokuqokelelwa kwamafutha amdaka, kuyathintela ukutya okutyelwe kakhulu. Ukusuka kumgaqo-siseko wohlalutyo, i-PQQ Ithintelo i-lipogenesis kwaye inciphisa ukuqokelela kwamafutha ngokuphucula ukusebenza kweMitochonduls kunye nokukhuthaza i-lipid metabolism.

I-05 ye-PQQ inokuthintela i-osteoporousis ebangelwa kukwaluphala kwendalo

NgoSeptemba 2023, iseli yokwaluphala yapapasha iPhepha loPhando elibambelele "i-Pyreraquinoline Quindoone i-osteoporosis yendalo ehambelana ne-nosteoporosis ye-Osteoporosis ye-Osteoporosis ye-MCM3-nAP1 Axis-theing upeblocation" kwi-Intanethi. Isifundo, ngovavanyo kwiimpuku, lafumanisa ukuba izongezo zokutya ze-PQQ zinokuthintela i-osteopororosis ezibangelwa kukwaluphala kwendalo. Indlela yokuxhasa i-Antioxidant ye-Antioxidant ibonelela ngovavanyo lokusetyenziswa kuka-PQQ njengesongezelelo sokutya ukuze sithintelwe i-osteoporosis enxulumene nexesha.
Olu phononongo lutyhila indima esebenzayo kunye nendlela entsha ye-PQQ ukhuseleko kunye nokunyanga i-Osteooporosis ye-Seneile, kwaye ingqina ukuba i-PQQ isetyenziswe njengesongezelelo esikhuselekileyo nelisebenzayo sokukhusela kunye nokunyanga i-Osteoporosis. Kwangelo xesha, kwatyhilwa ukuba i-PQQ isebenza i-MCM3-Keap1 ye-Keap2 i-Steoblals e-Antioxididant, i-gesis, iphakamisa ithambo le-ossoclast yethambo, ngokuthintela ukwaluphala. Indima ekwenzeni i-osteoporosis yesini.

I-06 eyongezelelekileyo ye-PQQ inokukhusela iiseli ze-retinal gallion kunye nokuphucula impilo yamehlo!

NgoSeptemba wama-2023, ijenali I-Orjeuro NeuroPatholhol parive School kunye neziphengululi ze-Eurouse Vistonia eVisa e-Itali. Litetwe "i-Pyrequinoline Quindone Drindone Drintas Synthesis eVitro naseVivo kwaye ibonelela nge-vivo kwaye ibonelela nge-retinal ganglion ye-neuroproteration." Uphando luqinisekisile ukuba i-PQQ inesiphumo esikhuselayo kwiiseli ze-retinal gallion (i-RGC) kwaye inamandla amakhulu e-IrourproPective kwi-Apoptoal Gaptosis ye-repoptoal graptosis.
Iziphumo zixhasa indima enokubakho ye-PQQ njenge-Iroproproprocetive ye-neuroprocetive ye-neroprocetive enokuphucula ukomelela kweeseli ze-retinal ganglion ngelixa kuncitshiswa umngcipheko weziphumo ebezingalindelekanga. Kwangelo xesha, abaphandi bakholelwa ukuba i-PQQ yongezelelo yindlela esebenzayo yokugcina impilo yamehlo.

I-07 yongeza i-PQQ inokulawula i-motorninal flora, ukuphucula ukusebenza kwe-hidiid, kunye nokunciphisa umonakalo we-thyroid.

NgoDisemba 2023, iqela lophando elivela kwisibhedlele sabantu besikolo saseShangjei seSikolo seMidlalo ye-Pyreloquineli kwiMicro J Microbione ilawula i-PQQ ye-PQQO, Ukunciphisa umonakalo wamathumbu, kunye nokuphucula ukusebenza kwe-hidroid.
Isifundo sifumene iimpembelelo ze-PQQ yesongezelelo kwi-GD iimpuku ze-GD kunye ne-flostinaal yazo:

I-01 emva kovavanyo lwe-PQQ, i-serum tshr kunye ne-T4 yeempuku ze-GD zancitshiswa, kwaye ubungakanani be-thland bancitshiswa kakhulu.

I-02 PQQ inciphisa ukuvuvukala kunye noxinzelelo lwe-oxidage, kwaye inciphise umonakalo omncinci we-epitifoal.

I-03 PQQ inefuthe elibonakalayo ekubuyiseleni iyantlukwano kunye nokuqulunqwa kwe-microbiota.

I-04 xa ithelekiswa neqela le-GD, unyango lwe-PQQ lunokunciphisa ubuninzi be-latobacillissi kwiimpuku (olu luncedo ekujoliswe kulo lwenkqubo ye-GD).

Kwisishwankathelo, isandiso se-PQQ sinokulawula ukusebenza kwe-Hiidroid, sinciphise umonakalo, kwaye sinciphise ukuvuvukala kunye noxinzelelo lwe-oxidage, ngaloo ndlela kunciphisa umonakalo omncinci. Kwaye i-PQQ inokubuyisela ukwahluka kwe-rolornional flora.

Ukongeza kwezi zifundo zingasentla zibonisa le ndima iphambili kunye ne-PQQ njengesongezelelo sokutya ukuphucula impilo, izifundo zangaphambili ziye zaqhubeka nokuqinisekisa imisebenzi enamandla ye-PQQ.

I-08 pqq inokuphucula i-pulmonary hypertered

Ngo-Okthobha 2022, iphepha lophando elithi "i-Pyreraquinoline Quine (PQQ) iphucule i-Promory Pirmonary Pirmonary kunye ne-Pitalis, ijolise ekuphuculeni i-Pillmonary hyperteon.
Iziphumo zibonisa ukuba i-PQQ inokuphelisa ukungasebenzi kwemithambo ye-mitochond kunye ne-metabolic kwi-pulmonary supering iiseli zemisipha kwaye zibazise ukuqhubela phambili i-ratpertereys kwiigundane; Ke ngoko, i-PQQ inokusetyenziswa njenge-arhente enokubakho esebenzayo ukuphucula i-hupmonary hyperteon.

I-09 pqq inokulibazisa ukuqina i-calile kwaye yandise ubomi!

NgoJanuwari 2020, iPhepha loPhando inesihloko sePyraquinoline Quidone Lilibazele ukuvunywa kwe-TNF-α igqitywe ngendlela ye-PFAL ye-PROL SURDISOL ye-PQQ kwiiseli zabantu. Iziphumo zibonisa ukuba i-pqq diseza i-algali yomntu kwaye inokuthi yandise ixesha lokuphila.

Abaphandi bafumanise ukuba i-PQQ iyakwazi ukulibazisa ukwaluphala komntu, kwaye iqinisekisile esi sigqibo ngeziphumo ze-biomamaskisi ezininzi ezinje nge-P21, P16, kwaye ihlawulwe1. Kucetyiswa ukuba i-PQQ inokuphucula impilo yabemi iyonke kwaye yandise ixesha lobomi.

I-10 pqq inokuthintela ukwaluphala kwe-ovari kwaye igcine ukuchuma

Ngo-Matshi 2022, iphepha lophando elinikezwe "i-PQQ yokutya i-PQQ ethintela ukungasebenzi kakuhle kwe-Avercrine-godcylin, ijolise ekufundeni ukuba ukungasebenzi kakuhle kwe-Alkylating. isiphumo.
Iziphumo zibonise ukuba i-PQQ yongezelelo inyuse ubunzima kunye nobungakanani bee-ovari, zibuyiselwe ngokuyinxalenye yomjikelo owonakeleyo, kwaye zithintele ukulahleka kweemplisi eziphathwayo ngeearhente ze-alkyeling. Ngaphaya koko, i-PQQ eyongezelelweyo ye-PQQ yonyuse kakhulu inqanaba lokukhulelwa kunye nobungakanani benkunkuma nganye nganye kwi-Alkylating I-Agement-I-Agement ye-Agement-I-Agement ye-Agement ye-Agement. Ezi ziphumo zibalaselisa amandla okungenelela kwe-PQQ yesongezelelo kwi-alkyelian engafakwanga i-ovarian.

Ukuqukumbela
Ngapha koko, njengesongezelelo esitsha sokutya, i-PQQ ivunyiwe ngemiphumo yawo elungileyo kwisondlo kunye nempilo. Ngenxa yemisebenzi yayo enamandla, ukhuseleko oluphezulu kunye nozinzo oluhle, lunamalungelo ophuhliso ebanzi kwicandelo lokutya okusebenzayo.
Kwiminyaka yakutshanje, ngokuqinana kolwazi, i-PQQ ifezekisile esona siqinisekiso sibanzi semfundo kwaye isetyenziswa ngokubanzi njengesongezelelo sokutya okanye ukutya eUnited States, eUbrope nakwamanye amazwe kunye nemimandla. Njengoko ulwazi lwabathengi basekhaya luyaqhubeka nokwenza nzulu, lukholelwa ukuba i-PQQ, njengesithako sokutya esitsha, siya kudala ilizwe elitsha kwimarike yasekhaya.

Izalathiso:

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