● Yintoni urolixin A
I-Urolithin A (efinyeziweyo njenge-UA) yindalo ye-polyphenol yendalo eveliswa yi-intestinal microbiota metabolism ye-ellagitannins. I-Ellagitannins ifumaneka ngokubanzi kukutya okufana neerharnati, amaqunube, amaqunube, iwalnuts, kunye newayini ebomvu. Xa abantu besitya oku kutya, i-ellagitannins iguqulwa ibe yi-urolithin A ngama-microbial athile emathunjini.
● Iimpawu ezisisiseko zeurolithin A
Igama lesiNgesi: Urolithin A
Inombolo ye-CAS: 1143-70-0
Ifomu yemolekyuli. : C₁₃H₈O₄
Ubunzima bemolekyuli: 228.2
Imbonakalo: Umgubo oqinileyo otyheli okanye okhanyayo
● I-Bioactivity kunye nokusebenza kakuhle kwe-urolixin A
1:Impembelelo yokuguga
Ukuphucula umsebenzi we-mitochondrial: i-urolithin A inokuvuselela i-mitophagy, inceda ukucacisa i-mitochondria eyonakalisiweyo, ikhuthaze ukuveliswa kwe-mitochondria entsha, esebenzayo, ukwenzela ukuba kugcinwe amandla e-metabolism yeeseli kunye nokulibazisa inkqubo yokuguga.Ukwandisa ubomi beeseli: Ngokuphucula imeko yokusebenza kweeseli kunye nokwandisa amandla eeseli, i-urolixin A inceda ukwandisa ubomi beeseli.
2:Impembelelo ye-neuroprotective
Ukunciphisa i-neuroinflammation: I-Urolitin A inokuwela umqobo we-blood-brain barrier, ukunciphisa i-amyloid beta (Aβ) kunye ne-tau protein lesions, kwaye ifake i-autophagy ye-mitochondrial, ngaloo ndlela iphucula iimpawu zezifo ze-neurodeergenerative ezifana nesifo se-Alzheimer kunye nesifo sika-Parkinson.Ukuphuculwa komsebenzi wememori: Izifundo ziye zabonisa ukuba i-urolixin, imemori kunye nemodeli ye-mitochondrial inokuphucula kakhulu.
3:Ukukhuselwa kwemisipha
Ukwandisa amandla emisipha kunye nokunyamezela: I-Urolixin A inokuphucula impilo ye-muscle, ikhulise amandla emisipha kunye nokunyamezela, kwaye inendima yokungenelela kwizifo ezinxulumene ne-muscular dystrophy.Ikhuthaza ukubuyiswa kwemisipha: Ngokulawula iindlela ezifana nokusebenza kwe-mitochondrial ngaphakathi kweeseli ze-muscle, i-urolixin A inceda abantu abadala okanye abantu abanobunzima bokuhamba ngenxa yesifo ukwenza umsebenzi ofunekayo wokubuyisela kunye nokukhuthaza ukubuyiswa kwemisipha.
4:I-Anti-inflammatory effect
Ukuvinjelwa kwezinto ezivuthayo: i-urolithin A inokuthintela ukuveliswa kunye nokukhululwa kwezinto ezivuthayo ezifana ne-IL-6 kunye ne-TNF-α, kunye nokunciphisa impendulo yokuvuvukala.Ukulawulwa kweendlela zokubonisa ukuvuvukala: Ngokuthintela ukusebenza kwe-NF-κB, i-MAPK kunye nezinye iindlela zokubonisa ukuvuvukala, i-urolitin A iyancipha ngakumbi impendulo yokuvuvukala.
5:i-antioxidation
Ukukhupha i-radicals yamahhala: I-Urolixin A inamandla okususa ngokuthe ngqo i-radicals yamahhala kunye nokunciphisa umonakalo wexinzelelo lwe-oxidative kwiiseli.
6:Impembelelo ye-Antitumor
Ukuvinjelwa kwe-tumor cell cell proliferation: i-urolixin A inokuthintela ukwanda, ukuhlasela kunye ne-metastasis yomhlaza we-prostate, umhlaza we-colon kunye nezinye iiseli ze-tumor.Ukufakwa kwe-tumor cell apoptosis: Ngokuvula iindlela zokubonisa ezinxulumene ne-apoptosis, i-urolixin A inokubangela i-tumor cell apoptosis, ngaloo ndlela inqanda ukukhula kwe-tumor.
7:Ukuphucula izifo ze-metabolic
Ukulawulwa kweswekile yegazi kunye negazi le-lipid: i-urolithin A inokulawula indlela yokuguqula umzimba kwaye idlale indima efanelekileyo ekuphuculeni iswekile yegazi kunye negazi le-lipid level.Anti-obesity: Ngokubangela ukusetyenziswa kwe-brown fat kunye ne-white fat Browning, i-urolixin A inokukhawulezisa i-fat catabolism kwaye inqande ukuqokelelwa kwamafutha okubangelwa kukutya.
8:Ukuphucula isifo sezintso
Ukunciphisa ukulimala kwezintso: I-Urolixin A inokunciphisa ukulimala kwezintso ngokuvula i-autophagy ye-mitochondrial yeeseli zezintso, ukunciphisa ukuqokelela kwe-collagen, ukunciphisa ukwanda kwe-fibrocyte okanye ukunciphisa i-fiber tissue deposition ukuze unciphise ukuphuhliswa kwenkqubo ye-fibrosis.
● Ithemba lokusetyenziswa kwe-urolithin A
1:Uphando lweziyobisi kunye nophuhliso
I-Urolixin A yinjongo ethandwayo yokuchasana nokuguga, i-neuroprotective, i-anti-tumor yophuhliso lweziyobisi ngenxa yemisebenzi yayo eyahlukeneyo yezinto eziphilayo.Okwangoku, Inani lamaziko ophando kunye namashishini aqalise ukufunda ukuphuhliswa kweziyobisi ze-urolixin A, enethemba lokuphuhlisa iziyobisi ezisebenzayo nezikhuselekileyo.
2:Uphando lwezithambiso kunye nophuhliso
I-antioxidant kunye ne-anti-inflammatory effects ye-urolixin A yenza ukuba ibe nethemba elibanzi lesicelo kwintsimi ye-cosmetics.Ngokongeza i-urolixin A, izimonyo zinokuphucula imiphumo yokuguga kunye nokuphucula imeko yesikhumba.
3:Uphando lokutya kunye nophuhliso
I-Urolixin A inexabiso elinokuthi lenze isicelo kwintsimi yokutya ngenxa yemisebenzi yayo eyahlukeneyo yezinto eziphilayo.Ngokongeza ukutya okucebileyo kwe-ellagitannin okanye i-urolithin A izongezelelo, ukutya kunokuphucula izibonelelo zempilo kunye nokuhlangabezana neemfuno zabathengi zokutya okunempilo.
Qhagamshelana:Judy Guo
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Ixesha lokuposa: Mar-27-2025